Local Drug Delivery Systems for Pain Management During and After Endodontic Therapy

Assessing postoperative pain after endodontic therapy.

Local anesthesia for endodontic pain

Why do patients avoid going to the dentist? According to a survey from the American Dental Association (1), fear of pain is the greatest factor that prevents patients from visiting their dentist. Additional surveys (2, 3) have found that 90% of dentists have some anesthetic difficulties during restorative dentistry procedures. In endodontics, Wallace and coworkers (4) surveyed Diplomates of the...

Local drug delivery agents as adjuncts to endodontic and periodontal therapy

In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained/controlled drug release, high antimicrobial activity and low systemic side effects. The conventional method for the elimination of subgingival microbial infection includes mechani...

Percutaneous dermal drug delivery for local pain control

Topical anesthetics have evolved from a simple solution of cocaine to creams, ointments, gels, liposomal preparations, and to the latest sophisticated patches and peels. Topical anesthetics are essential for performing diagnostic, therapeutic, and cosmetic dermatology procedures. These anesthetics noninvasively deliver anesthesia in locally required areas. In this review, we present an overview...

Pluronic as nano-carier for drug delivery systems

A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such mater...